Los Angeles County (along with California and the remaining United States) is in the worse overdose crisis in our history, driven by fentanyl and methamphetamine. No community is unimpacted by overdose, which spares no racial, ethnic, socioeconomic status, or age group. The historic response to substance-related crisis – to encourage people who use drugs to seek substance use treatment – is a necessary but insufficient response with when not paired with robust prevention and harm reduction initiatives that reach the people most in need. 94% of people with substance use disorders do not obtain substance use treatment, and 96.8% of this group do not seek treatment because they are not interested in participating in treatment as usual. Responding to overdose therefore requires our reaching those who are not currently participating in treatment services.